Products

Cebaktal

CEBACTAL®

Suspension for injections

Description

Opaque light yellow liquid.

Composition

1 ml of the drug contains:

active ingredient: cefquinome sulfate – 29.64 mg;

excipients - colza oil, propylparahydroxybenzoate, methylparahydroxybenzoate.

Pharmacological properties

АТСvet: QJ01. Antibacterials for systemic use. QJ01DE90. Cefquinome.

Cefquinome is the fourth generation cephalosporin, which has a broad spectrum of antibacterial action against most gram-positive and gram-negative bacteria, particularly, including but not limited to Escherichia coli, Enterobacter spp., Staphylococcus aureus, Streptococcus spp., Clostridium spp., Actinobacillus spp., Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Histophilus somni, Arcanobacterium pyogenes, Bacillus spp., Corynebacterium spp., Bacteroides spp., Fusobacterium spp., Prevotella spp. and Erysipelothrix rhusiopathiae as well as against β-lactamase producing strains. The mechanism of bactericidal effect consists in inhibition of cell membrane synthesis in microorganisms.

After parenteral administration cefquinome penetrates into systemic circulation, reaching its maximum concentration in blood serum in 60-90 minutes in cattle and 15-60 minutes in swine and being maintained at therapeutic level for 24 hours. The level of binding of cefquinome with proteins of blood serum does not exceed 5%. Cefquinome is relatively easy eliminated from the body (half-life period makes 2-2.5 hours in cattle and 9 hours in swine), primarily in unchanged form with urine.

Administration

Cattle: treatment of animals against acute mastitis (including mastitis caused by Escherichia coli), escherichiosis (colibacillosis), respiratory diseases caused by Pasteurella multocida, P. haemolytica and other cefquinome-sensitive microorganisms as well as panaritium, hoof sole ulcer, purulent pododermatitis, septicemia, bacterial interdigital dermatitis and necrobacillosis.

Swine: treatment of animals against MMA (mastitis-metritis-agalactia) syndrome, meningitis, arthritis, dermatitis as well as diseases of respiratory organs caused by Pasteurella multocida, Haemophillus parasuis, Actinobacillus pleuropneumoniae, Streptococcus suis and other cefquinome-sensitive bacteria.

Dosage

The drug is administered deep intramuscularly once daily in the following doses:

 

Animal species

Indications

Daily drug dose (per 10 kg body weight)

Duration of treatment 

Cattle

Diseases of respiratory organs, interdigital necrobacillosis or dermatitis

0.4 ml

3-5 days

Acute mastitis

0.4 ml

2 days

Escherichiosis (colibacillosis) in calves

0.8 ml

3-5 days

Swine

Diseases of respiratory organs

0.8 ml

3 days

MMA syndrome

0.8 ml

2 days

Meningitis, arthritis, dermatitis

0.8 ml

5 days

 

Contraindications

Do not administer to animals sensitive to the drug and other β-lactam antibiotics. Do not prescribe in combination with bacteriostatics.

Precautions

Shake the vial intensely before every use. It is recommended that the injection site be changed throughout the treatment period to prevent local reaction. Avoid omission of regular drug administration as it may decrease therapeutic efficacy. In case a single dose is omitted, make injection as soon as possible with subsequent intervals between injections being unchanged.

Animal slaughter for meat is possible in 8 days (cattle) and 4 days (swine) following the last administration of the drug. Milk may be consumed in 3 days following the last administration of the drug. Meat and milk obtained before the mentioned term shall be utilized or fed to non-productive animals depending on the statement of veterinary physician. 

Packaging

Glass vials of 100 ml sealed with rubber stoppers and aluminum caps.

Storage

Store in a dark place out of the reach of children at 2-30°С.

Shelf life

2 years. 

Use the drug within 28 days following the initial sampling from the vial provided it is stored in a dry, dark place at 2-8°С.