Powder for oral administration
1 g of the drug contains:
active ingredient: nosiheptide – 5 mg;
excipient - semolina up to 1 g.
АТСvet: QA07A. Intestinal anti-infectives.
Nosiheptide is an antibiotic of the polypeptides group. It makes bactericidal effect upon gram-positive microorganisms (Clostridium perfringens, Streptococcus spp., Staphylococcus spp.) as well as upon certain gram-negative microorganisms (Pasteurella multocida, Neisseria catarrhalis). Nosiheptide makes effect upon bacterial synthesis of proteins, that is – upon 50S ribosomal subunits, and tightly binds the 23S-rRNA complex to the ribosomal protein L11. It is not absorbed from the digestive tract, therefore, it makes impact exclusively upon intestinal microflora. It inhibits growth of microorganisms producing ammonia, facilitating reduction of the ammonia level in digestive tract.
The resistance of bacteria to the active ingredient develops slowly. No resistance of Clostridium perfringens is observed. No cross-resistance with other antibacterial preparations is observed in microorganisms.
High concentration of nosiheptide formed in the digestive tract contributes to long-term antibacterial effect. It is not accumulated in body tissues and is eliminated from the body in unchanged form.
Prevention and treatment of diseases of digestive tract (particularly – of necrotic enteritis) caused by microorganisms sensitive to the active ingredient of the drug in poultry.
The drug is applied by group method mixed with the feed in the following doses:
- young poultry: 500 g/t of feed throughout the growing period;
- laying hens and broiler parental stocks: 400-500 g/t of feed;
- suckling piglets, growing-fattening piglets, main sows and boars: 600-1000 g/t of feed;
- pregnant and lactating saws: 1600-2000 g/t of feed;
- calves of up to 3 months of age: 600-1000 g/t of feed;
- rabbits: 1-2 g/kg of feed throughout the growing period.
Do not use to treat animals with hypersensitivity to the active ingredient of the drug.
Do not use Bionon® in sub-therapeutic doses.
Multilayer paper bags of 1 and 25 kg.
Store in a dry dark place out of the reach of children at 5-30°С.